Human Growth Hormone (DAG372)

Human Growth Hormone, recombinant protein from E. coli

Product Overview
RecombinantHuman growth hormone (hGH) is a single, non-glycosylated, polypeptide chaincontaining 192 amino acids. Molecular weight: 22,260Da. The sequence of thefirst five N-terminal amino acids was determined to be Met-Phe-Pro-Thr-Ile
Nature
Recombinant
Tag/Conjugate
Unconjugated
Procedure
None
Format
Purified, Lyophilized. Reconstitute using sterile deionized water to a concentration ≥100μg/ml.Further dilutions can be made in other aqueou buffers.
Concentration
Totalprotein: 1 mg/ml (OD280nm, E0.1% = 0.72) Activity: 3Units/mg
Buffer
Lyophilized fromsodium phosphate buffer containing mannitol
Preservative
None
Storage
2-8°C short term, -20°C long term
Introduction
The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. The five genes share a remarkably high degree of sequence identity. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. This particular family member is expressed in the pituitary but not in placental tissue as is the case for the other four genes in the growth hormone locus. Mutations in or deletions of the gene lead to growth hormone deficiency and short stature.
Antigen Description
Growth hormone (GH) is aprotein-based peptide hormone. It stimulates growth, cell reproduction andregeneration in humans and other animals. Growth hormone is a 191-amino acid,single-chain polypeptide that is synthesized, stored, and secreted by thesomatotroph cells within the lateral wings of the anterior pituitary gland.Somatotropin refers to the growth hormone 1 produced naturally in animals,whereas the term somatropin refers to growth hormone produced by recombinant DNA technology, and is abbreviated HGH in humans.
Keywords
GH; IGHD1B; GH-N; Somatotropin; GHN; Growth hormone; hGH-N; GH1; HGH

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