Human Apolipoprotein A-I

Product Overview

A complexof human Apolipoprotein A-I and 1-palmitoyl-2-oleoyl phosphatidylcholine wasexpressed in Human Plasma prepared at a molar ratio of 1 to 100 by thecholate removal method. rHDL has been useful in studies of cholesteroltransport, anti-inflammatory m

Nature

Recombinant

Tag/Conjugate

Unconjugated

Format

Purified, Liquid

Concentration

1 mg/mlprotein (BCA) 2.7 mg/ml (POPC)

Buffer

100mM Sodiumchloride, 10mM Tris, 1mM EDTA, pH 7.4

Preservative

0.01% Sodium Azide

Storage

2-8°C short term, -20°C long term

Introduction

This gene encodes apolipoprotein A-I, which is the major protein component of high density lipoprotein (HDL) in plasma. The protein promotes cholesterol efflux from tissues to the liver for excretion, and it is a cofactor for lecithin cholesterolacyltransferase (LCAT) which is responsible for the formation of most plasma cholesteryl esters. This gene is closely linked with two other apolipoprotein genes on chromosome 11. Defects in this gene are associated with HDL deficiencies, including Tangier disease, and with systemic non-neuropathic amyloidosis. [provided by RefSeq, Jul 2008]

Antigen Description

HDL is a cholesterol carrier protein that actsas scavenger of tissue cholesterol. It is important in cholesterol efflux fromtissues, and involved in the return of cholesterol from the periphery to theliver for removal as bile acids.

Keywords

APOA1; apolipoprotein A-I; apo-AI;