This gene encodes apolipoprotein A-I, which is the major protein component of high density lipoprotein (HDL) in plasma. The protein promotes cholesterol efflux from tissues to the liver for excretion, and it is a cofactor for lecithin cholesterolacyltransferase (LCAT) which is responsible for the formation of most plasma cholesteryl esters. This gene is closely linked with two other apolipoprotein genes on chromosome 11. Defects in this gene are associated with HDL deficiencies, including Tangier disease, and with systemic non-neuropathic amyloidosis. [provided by RefSeq, Jul 2008]
Pathway
ABC-family proteins mediated transport; ABCA transporters in lipid homeostasis; African trypanosomiasis; Amyloids; Binding and Uptake of Ligands by Scavenger Receptors; Chylomicron-mediated lipid transport; Disease; Diseases associated with visual transduction
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