This gene encodes apolipoprotein A-I, which is the majorprotein component of high density lipoprotein (HDL) in plasma. Theprotein promotes cholesterol efflux from tissues to the liver forexcretion, and it is a cofactor for lecithincholesterolacyltransferase (LCAT) which is responsible for theformation of most plasma cholesteryl esters. This gene is closelylinked with two other apolipoprotein genes on chromosome 11.Defects in this gene are associated with HDL deficiencies,including Tangier disease, and with systemic non-neuropathicamyloidosis.
Pathway
ABC-family proteins mediated transport; ABCA transporters in lipid homeostasis; African trypanosomiasis; Amyloids; Binding and Uptake of Ligands by Scavenger Receptors; Chylomicron-mediated lipid transport; Disease; Diseases associated with visual transduction;
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