Human RANBP2 peptide

Nature

Synthetic

Tag/Conjugate

Unconjugated

SequenceSimilarities

Contains 1 PPIase cyclophilin-type domain.Contains 4 RanBD1 domains.Contains 8 RanBP2-type zinc fingers.Contains 1 TPR repeat.

Alternative Names

Contains F-X-F-G repeats.

Format

Liquid

Preservative

None

Storage

Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. Information available upon request.

Entrez Gene ID

Antigen Description

RAN is a small GTP-binding protein of the RAS superfamily that is associated with the nuclear membrane and is thought to control a variety of cellular functions through its interactions with other proteins. This gene encodes a very large RAN-binding protein that immunolocalizes to the nuclear pore complex. The protein is a giant scaffold and mosaic cyclophilin-related nucleoporin implicated in the Ran-GTPase cycle. The encoded protein directly interacts with the E2 enzyme UBC9 and strongly enhances SUMO1 transfer from UBC9 to the SUMO1 target SP100. These findings place sumoylation at the cytoplasmic filaments of the nuclear pore complex and suggest that, for some substrates, modification and nuclear import are linked events. This gene is partially duplicated in a gene cluster that lies in a hot spot for recombination on chromosome 2q. [provided by RefSeq, Jul 2008]

Function

RNA binding; Ran GTPase binding; ligase activity; peptidyl-prolyl cis-trans isomerase activity; protein binding; zinc ion binding;

Synonyms

RANBP2; RAN binding protein 2; ANE1; TRP1; TRP2; ADANE; IIAE3; NUP358; E3 SUMO-protein ligase RanBP2; P270; nucleoporin 358; nucleoporin Nup358; 358 kDa nucleoporin; ran-binding protein 2; transformation-related protein 2; nuclear pore complex protein Nup358; acute necrotizing encephalopathy 1 (autosomal dominant);