Specifications
Immunogen
Synthetic peptide conjugated to KLH derived from within residues 3100 - 3200 RanBP2.
Target
Alternative Names
RANBP2; RAN binding protein 2; E3 SUMO-protein ligase RanBP2; NUP358; P270; nucleoporin 358; nucleoporin Nup358; 358 kDa nucleoporin; ran-binding protein 2; transformation-related protein 2; nuclear pore complex protein Nup358; ANE1; TRP1; TRP2; IIAE3;
Product Background
Antigen Description
E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I. Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates. Could also have isomerase or chaperone activity and may bind RNA or DNA. Component of the nuclear export pathway. Specific docking site for the nuclear export factor exportin-1.
Pathway
Antiviral mechanism by IFN-stimulated genes, organism-specific biosystem; Cell Cycle, organism-specific biosystem; Cell Cycle, Mitotic, organism-specific biosystem; Cytokine Signaling in Immune system, organism-specific biosystem; DNA Replication, organism-specific biosystem; Disease, organism-specific biosystem; Export of Viral Ribonucleoproteins from Nucleus, organism-specific biosystem;
Citations
Publication ()
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COA
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