The protein encoded by this gene is a ubiquitously expressed nuclear protein. It is found among several proteins that bind directly to retinoblastoma protein, which regulates cell proliferation. This protein complexes with transcriptional co-repressor CTBP. It is also associated with BRCA1 and is thought to modulate the functions of BRCA1 in transcriptional regulation, DNA repair, and/or cell cycle checkpoint control. It is suggested that this gene may itself be a tumor suppressor acting in the same pathway as BRCA1. Three transcript variants encoding two different isoforms have been found for this gene. More transcript variants exist, but their full-length natures have not been determined. [provided by RefSeq, Jul 2008]
Function
RNA polymerase II repressing transcription factor binding; RNA polymerase II transcription corepressor activity; damaged DNA binding; protein binding; single-stranded DNA endodeoxyribonuclease activity
Synonyms
RBBP8; retinoblastoma binding protein 8; RIM; COM1; CTIP; JWDS; SAE2; SCKL2; DNA endonuclease RBBP8; RBBP-8; CTBP-interacting protein; sporulation in the absence of SPO11 protein 2 homolog
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