Specifications
Immunogen
Synthetic peptide corresponding to residues in Human CtIP (Uniprot Q99708).
Applications
Application Notes
WB: 1/1000 - 1/10000; Flow Cyt: 1/100 - 1/500.
Target
Alternative Names
RBBP8; retinoblastoma binding protein 8; retinoblastoma binding protein 8 , SCKL2, Seckel syndrome 2; DNA endonuclease RBBP8; CTBP interacting protein; CtIP; RIM; RBBP-8; CTBP-interacting protein; sporulation in the absence of SPO11 protein 2 homolog; CT
Product Background
Antigen Description
Endonuclease that cooperates with the MRE11-RAD50-NBN (MRN) complex in processing meiotic and mitotic double-strand breaks (DSBs) by ensuring both resection and intrachromosomal association of the broken ends. Functions downstream of the MRN complex and ATM, promotes ATR activation and its recruitment to DSBs in the S/G2 phase facilitating the generation of ssDNA. Component of the BRCA1-RBBP8 complex that regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage. Promotes microhomology-mediated alternative end joining (A-NHEJ) during class-switch recombination and plays an essential role in chromosomal translocations.
Pathway
BARD1 signaling events, organism-specific biosystem; E2F transcription factor network, organism-specific biosystem; Meiosis, organism-specific biosystem; Meiotic Recombination, organism-specific biosystem; Notch signaling pathway, organism-specific biosystem; Notch-mediated HES/HEY network, organism-specific biosystem.
Citations
Publication ()
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COA
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