Human RBBP8 peptide

Nature

Synthetic

Tag/Conjugate

Unconjugated

SequenceSimilarities

Belongs to the COM1/SAE2/CtIP family.

Alternative Names

The PXDLS motif binds to a cleft in CtBP proteins.The damage-recruitment motif is required for DNA binding and translocation to sites of DNA damage.

Purity

70 - 90% by HPLC.

Format

Liquid

Preservative

None

Storage

Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. Information available upon request.

Entrez Gene ID

Antigen Description

The protein encoded by this gene is a ubiquitously expressed nuclear protein. It is found among several proteins that bind directly to retinoblastoma protein, which regulates cell proliferation. This protein complexes with transcriptional co-repressor CTBP. It is also associated with BRCA1 and is thought to modulate the functions of BRCA1 in transcriptional regulation, DNA repair, and/or cell cycle checkpoint control. It is suggested that this gene may itself be a tumor suppressor acting in the same pathway as BRCA1. Three transcript variants encoding two different isoforms have been found for this gene. More transcript variants exist, but their full-length natures have not been determined. [provided by RefSeq, Jul 2008]

Function

RNA polymerase II repressing transcription factor binding; RNA polymerase II transcription corepressor activity; damaged DNA binding; protein binding; single-stranded DNA endodeoxyribonuclease activity;

Synonyms

RBBP8; retinoblastoma binding protein 8; RIM; COM1; CTIP; JWDS; SAE2; SCKL2; DNA endonuclease RBBP8; RBBP-8; CTBP-interacting protein; sporulation in the absence of SPO11 protein 2 homolog;