Phosphorylcholine [BSA], High loaded

A new KNN-based lead-free piezoelectric material system of (1-x)K0.4Na0.6Nb0.96Sb0.04O3-x(Bi0.45Sm0.05) Na0.5ZrO3 (abbreviated as KNNS-xBSNZ, 0.00 <= x <= 0.06) is designed to obtain high performance to meet the requirement of next generation electronic devices. The relevant electric properties such as piezoelectricity, strain, and temperature stability are analyzed in detail. An excellent comprehensive property (d(33)similar to 508 pC/N, T-C similar to 268 degrees C) is obtained in ceramic with x = 0.04 through the construction of rhombohedral-orthorhombic-tetragonal (R-O-T) phase boundary. In addition, a good temperature stability of strain for KNNS-0.04BSNZ ceramic is also obtained within the range from room temperature to 175 degrees C (S-uni100 degrees C/S-uniRT similar to 97.81%, S-uni150 degrees C/S-uniRT similar to 84.67%), which is comparatively superior to some reported KNN-based ceramics and lead-based ceramics. Therefore, we believe that this new material system would be a promising lead-free candidate for the practical applications. (C) 2020 Elsevier B.V. All rights reserved.

Background: Clinical diagnosis of post-hepatectomy liver failure (PHLF) can only be made on or after the 5th postoperative day. Biomarker for early diagnosis is considered as a critical unmet need. Methods: Twenty domestic female crossbreed (Yorkshire-landrace and duroc) pigs underwent sham operation (n=6), 70% (n=7) and 90% (n=7) partial hepatectomy (PH). A comprehensive lipidomic analysis was conducted using sera collected at pre-operation (PO), 14, 30, and 48 h after PH using nanoflow ultrahigh performance liquid chromatography-electrospray ionization-tandem mass spectrometry. Results: Of the 184 quantified lipids, 14 lipids showed significant differences between the two resection groups starting at 30 h after surgery. Four phosphatidylcholine (PC) plasmalogen species (P-16:0/16:0, P-18:0/18:2, P-18:0/20:4, and P-18:0/22:6) and PC 32:2 significantly increased in the 90% PH group while these returned to PO level after 30 h in the 70% PH group, presumably implying the failure markers. In contrast, eight triacylglycerol (TG) species (40:0, 42:1, 42:0, 44:1, 44:2, 46:1, 46:2, and 48:3) and sphingomyelin d18:1/20:0 showed an opposite trend, wherein they significantly decreased in the 90% PH group while these in the 70% PH group were abruptly increased until 30 h but returned to near PO levels at 48 h, implying the recovery markers. Same trends could also be observed in the level of whole lipid classes of PC plasmalogens and TGs, in addition to selected individual lipid species. Conclusions: Characteristic lipidomic signatures of PHLF could be identified using large animal models. These candidates have a potential to serve as a tool for early diagnosis and may open new paths to the study to overcome PHLF.