Human BBC3 blocking peptide

Nature

Synthetic

Tag/Conjugate

Unconjugated

SequenceSimilarities

BBC3 peptide is a synthetic peptide corresponding to the internal region of BBC3.

Purity

> 95 % by SDS-PAGE.

Format

Lyophilized

Preservative

0.02% Sodium Azide

Storage

Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. PBS with 0.1% BSA 0.02% sodium azide pH7.2

Reconstitution

BBC3 peptide is supplied as 1mg of dried peptide. When the peptide is reconstituted in 1 mL strile water, the concentration will be 1 mg/mL.

Introduction

This gene encodes a member of the BCL-2 family of proteins. This family member belongs to the BH3-only pro-apoptotic subclass. The protein cooperates with direct activator proteins to induce mitochondrial outer membrane permeabilization and apoptosis. It can bind to anti-apoptotic Bcl-2 family members to induce mitochondrial dysfunction and caspase activation. Because of its pro-apoptotic role, this gene is a potential drug target for cancer therapy and for tissue injury. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011]

Entrez Gene ID

Synonyms

BBC3; BCL2 binding component 3; JFY1; PUMA; JFY-1; bcl-2-binding component 3; p53 up-regulated modulator of apoptosis;