Synthetic Human BBC3 blocking peptide for BL
Belongs to the Bcl-2 family.
Mitochondrion. Localized to the mitochondria in order to induce cytochrome c release.
PBS with 0.1% BSA 0.02% sodium azide pH7.2
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. PBS with 0.1% BSA 0.02% sodium azide pH7.2
This gene encodes a member of the BCL-2 family of proteins. This family member belongs to the BH3-only pro-apoptotic subclass. The protein cooperates with direct activator proteins to induce mitochondrial outer membrane permeabilization and apoptosis. It can bind to anti-apoptotic Bcl-2 family members to induce mitochondrial dysfunction and caspase activation. Because of its pro-apoptotic role, this gene is a potential drug target for cancer therapy and for tissue injury. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011]
BBC3; BCL2 binding component 3; JFY1; PUMA; JFY-1; bcl-2-binding component 3; p53 up-regulated modulator of apoptosis;