Specifications
Species Reactivity
Mouse; Rat; Human
Immunogen
Recombinant fragment corresponding to Human PUMA alpha aa 76-170.Sequence: RWPGGPRSRPRGPRPDGPQPSLSLAEQHLESPVPSAPGALAGGPTQAAPG VRGEEEQWAREIGAQLRRMADDLNAQYERRRQEEQQRHRPSPWRV Database link: Q9BXH1-1
Applications
Application Notes
WB: 2.5 - 5 μg/ml;
Target
Alternative Names
BBC3; BCL2 binding component 3; bcl-2-binding component 3; JFY1; PUMA; p53 up-regulated modulator of apoptosis; JFY-1; FLJ42994;
Product Background
Antigen Description
PUMA is localised to the mitochondria, binds BCL-2 and induces cytochrome C release and apoptosis in response to p53. PUMA is indeed an essential mediator of p53-dependent and -independent apoptosis in vivo, mediates the apoptotic response to p53 in colorectal cancer cells and is degraded during Chlamydia trachomatis infection
Pathway
Activation of BH3-only proteins, organism-specific biosystem; Activation of PUMA and translocation to mitochondria, organism-specific biosystem; Apoptosis, organism-specific biosystem; Apoptosis, organism-specific biosystem; BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members, organism-specific biosystem; Direct p53 effectors, organism-specific biosystem; Huntingtons disease, organism-specific biosystem;
Citations
Publication ()
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COA
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