a synthetic peptide corresponding to 14 amino acids near the amino-terminus of human PUMA-a. This sequence is identical between a and b forms of the PUMA proteins.
This gene encodes a member of the BCL-2 family of proteins. This family member belongs to the BH3-only pro-apoptotic subclass. The protein cooperates with direct activator proteins to induce mitochondrial outer membrane permeabilization and apoptosis. It can bind to anti-apoptotic Bcl-2 family members to induce mitochondrial dysfunction and caspase activation. Because of its pro-apoptotic role, this gene is a potential drug target for cancer therapy and for tissue injury. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011]
Pathway
Activation of BH3-only proteins; Activation of PUMA and translocation to mitochondria; Apoptosis; Apoptosis Modulation and Signaling; BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members; DNA damage response; DNA damage response (only ATM dependent); Direct p53 effectors
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