Anti-Psmb11 polyclonal antibody

Antibody Isotype

IgG

Conjugate

Alternative Names

beta5t; 5830406J20Rik

Entrez Gene ID

UniProt ID

Antigen Description

The 20S proteasome is composed of 28 subunits, arranged as a cylinder-shaped structure made of four stacked hetero-heptameric rings: ?1-7, ?1-7, ?1-7, and ?1-7. ?1, ?2, and ?5 function the catalytic subunit for proteolysis. Murata and colleagues recently identified a new catalytic ? subunit called ?5t, which is only expressed in thymic cortical epithelial cells and dominantly incorporated into thymic 20S proteasomes. The integration of ?5t into proteasomes reduces their chymotrypsin-like activity responsible for producing high affinity peptides for MHC class I. The depletion of ?5t in mice resulted in defective development of CD8 single positive T cells in the thymus, indicating that ?5t has a key role for generating the MHC class I-restricted CD8+T cell repertoire during thymic selection. There results challenge the 15 years old theory of T-cell development, particularly positive selection in the thymus and the phenomenon of peripheral tolerance.

Pathway

APC/C-mediated degradation of cell cycle proteins, organism-specific biosystem;APC/C:Cdc20 mediated degradation of Securin, organism-specific biosystem;APC/C:Cdc20 mediated degradation of mitotic proteins, organism-specific biosystem;APC/C:Cdh1 mediated d