The protein encoded by this gene is a serine/threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. The activated form of the encoded protein can phosphorylate translation initiation factor EIF2S1, which in turn inhibits protein synthesis. This protein is also activated by manganese ions and heparin. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Function
ATP binding; double-stranded RNA binding; eukaryotic translation initiation factor 2alpha kinase activity; non-membrane spanning protein tyrosine kinase activity; poly(A) RNA binding; protein binding; protein kinase activity; protein kinase activity; protein phosphatase type 2A regulator activity; protein serine/threonine kinase activity
Synonyms
EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2; PKR; PRKR; EIF2AK1; PPP1R83; interferon-induced, double-stranded RNA-activated protein kinase; p68 kinase; eIF-2A protein kinase 2; P1/eIF-2A protein kinase; tyrosine-protein kinase EIF2AK2; interferon-inducible elF2alpha kinase; double stranded RNA activated protein kinase; protein phosphatase 1, regulatory subunit 83; protein kinase, interferon-inducible double stranded RNA dependent
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