Rat Ovalbumin specific Immunoglobulin E ELISA Kit

Renal interstitial cell tumor (RICT) is a rare renal sarcoma of dogs that arises from renal interstitial cells. Herein we describe a RICT in an 8-y-old female Labrador Retriever dog that died after a 2-d history of lethargy and disorientation. Grossly, soft white nodules of 1-10 mm diameter were present in the renal cortex and corticomedullary junction of both kidneys, left cardiac ventricular wall, and right cerebral hemisphere. A pale-white to yellow, firm, irregular mass effaced 80% of the right pulmonary parenchyma, involving mainly the cranial and middle lobes, and the adjacent tracheobronchial lymph nodes. Histologically, the renal, myocardial, and cerebral neoplasm consisted of interlacing bundles of stellate-to-spindle cells with eosinophilic vacuolated cytoplasm and round-to-oval nuclei with finely stippled chromatin. The mitotic count was 28 per 2.37 mm(2). Alcian blue stain revealed an extracellular myxomatous matrix throughout the neoplasm. Neoplastic cells had cytoplasmic immunolabeling for vimentin and cyclooxygenase 2. The pulmonary and tracheobronchial neoplasm consisted of infiltrative nodules of cuboidal epithelial cells that had a moderate amount of eosinophilic cytoplasm and round nuclei with coarsely stippled chromatin. There were 5 mitoses per 2.37 mm(2). Neoplastic cells had cytoplasmic and nuclear immunolabeling for cytokeratin AE1/AE3 and thyroid transcription factor 1, respectively. Morphologic and immunohistochemical findings were consistent with a RICT with cardiac and cerebral metastases, and a pulmonary carcinoma with tracheobronchial lymph node metastasis.

Purpose. To provide quantitative measurements for the foveal avascular zone (FAZ) and to describe its morphological characteristics by optical coherence tomography angiography (OCT-A).Design. Cross-sectional observational case series.Methods. Healthy volunteers were recruited and evaluated using Triton-DRI SS-OCT Angiography. A 4.5 x 4.5 mm square was evaluated by OCT-A center around the fovea. Superficial and deep capillary plexus were identified, and different quantitative measurements were conducted along with categorization of the FAZ pattern.Results. Eighty-two eyes (41 volunteers) were evaluated. Mean age was 30.59 +/- 7.6 years (23-42 years). Mean subcentral retinal thickness was 200.1 +/- 5.66 um (192-210 um). The number of terminal vessels was variable (range, 8-11). Mean maximum terminal vessel-to-vessel intervening distance was 527.8 +/- 60.3 um (471-674 um). Mean minimum terminal vessel-to-vessel intervening distance was 296.7 +/- 45.8 um (233-373 um). Mean maximum horizontal diameter of FAZ (superficial) was 716.17 +/- 124.09 um, while mean maximum vertical diameter of FAZ (superficial) was 667.76 +/- 131.28 um. Mean maximum horizontal diameter of FAZ (deep) was 823.19 +/- 144.92 um, while mean maximum vertical diameter of FAZ (deep) was 794.03 +/- 150.28 um. OCT-A detected different FAZ patterns; horizontally oval configuration in 32 eyes (39%), rounded configuration in 24 eyes (29.3%), pentagon configuration in 14 eyes (17.1%), and vertically oval and nonspecific configuration in 6 eyes each (7.3%).Conclusion. OCT-A could efficiently provide both quantitative and qualitative assessment of normal FAZ; such characterizations were difficult by standard FAZ assessment procedures like FFA.