Specificity
Ubiquitously expressed. Found as well in all tumor cell lines analyzed, amplified in sarcomas. Highly expressed in osteosarcoma OSA-CL and rhabdomyosarcoma RH30 cell lines. Isoform 2 is the major isoform detected in all cell types examined.
Tag/Conjugate
Unconjugated
SequenceSimilarities
Belongs to the OS-9 family.Contains 1 PRKCSH domain.
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. Information available upon request.
Antigen Description
This gene encodes a protein that is highly expressed in osteosarcomas. This protein binds to the hypoxia-inducible factor 1 (HIF-1), a key regulator of the hypoxic response and angiogenesis, and promotes the degradation of one of its subunits. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Function
glycoprotein binding; protease binding; protein binding;
Synonyms
OS9; osteosarcoma amplified 9, endoplasmic reticulum lectin; OS-9; ERLEC2; protein OS-9; erlectin 2; amplified in osteosarcoma 9; endoplasmic reticulum lectin 2; osteosarcoma amplified 9, endoplasmic reticulum associated protein;
Citations
Publication ()
Have you cited DAG-P1849 in a publication?
Let us know and earn a reward for your research.
COA
Loading ......
