This gene encodes a protein that is highly expressed in osteosarcomas. This protein binds to the hypoxia-inducible factor 1 (HIF-1), a key regulator of the hypoxic response and angiogenesis, and promotes the degradation of one of its subunits. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Pathway
HRD1/SEL1 ERAD complex, organism-specific biosystem; HRD1/SEL1 ERAD complex, conserved biosystem; Hypoxic and oxygen homeostasis regulation of HIF-1-alpha, organism-specific biosystem; Protein processing in endoplasmic reticulum, organism-specific biosystem; Protein processing in endoplasmic reticulum, conserved biosystem;
Custom Antibody Labeling
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More
Citations
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Kolb, EA; Kamara, D; et al. R1507, A Fully Human Monoclonal Antibody Targeting IGF-1R, Is Effective Alone and in Combination With Rapamycin in Inhibiting Growth of Osteosarcoma Xenografts. PEDIATRIC BLOOD & CANCER 55:67-75(2010).
RAHA, D; CARLSON, J; et al. OS9 - A NOVEL OLFACTORY GENE OF DROSOPHILA EXPRESSED IN 2 OLFACTORY ORGANS. JOURNAL OF NEUROBIOLOGY 25:169-184(1994).
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COA
Certificate of Analysis
