Specifications
Species Reactivity
Mouse; Rat; Human
Immunogen
A synthetic peptide of human OS9 is used for rabbit immunization.
Target
Alternative Names
OS9; osteosarcoma amplified 9, endoplasmic reticulum lectin; protein OS-9; endoplasmic reticulum lectin 2; ERLEC2; erlectin 2; OS 9; amplified in osteosarcoma 9; osteosarcoma amplified 9, endoplasmic reticulum associated protein; OS-9;
Product Background
Antigen Description
This gene encodes a protein that is highly expressed in osteosarcomas. This protein binds to the hypoxia-inducible factor 1 (HIF-1), a key regulator of the hypoxic response and angiogenesis, and promotes the degradation of one of its subunits. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Pathway
HRD1/SEL1 ERAD complex, organism-specific biosystem; HRD1/SEL1 ERAD complex, conserved biosystem; Hypoxic and oxygen homeostasis regulation of HIF-1-alpha, organism-specific biosystem; Protein processing in endoplasmic reticulum, organism-specific biosystem; Protein processing in endoplasmic reticulum, conserved biosystem;
Citations
Publication ()
Have you cited DCABH-12729 in a publication?
Let us know and earn a reward for your research.
COA
Loading ......
