Lectin which functions in endoplasmic reticulum (ER) quality control and ER-associated degradation (ERAD). May bind terminally misfolded non-glycosylated proteins as well as improperly folded glycoproteins, retain them in the ER, and possibly transfer them to the ubiquitination machinery and promote their degradation. Possible targets include TRPV4.
Pathway
HRD1/SEL1 ERAD complex; Hypoxic and oxygen homeostasis regulation of HIF-1-alpha; Protein processing in endoplasmic reticulum;
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