Anti-MMP9 monoclonal antibody, clone TC26d

Antibody Isotype

IgG2a

Clone

TC26d

Species Reactivity

Human

Immunogen

Recombinant protein corresponding to human MMP9.

Conjugate

Application Notes

ELISA (1:3000-1:8000); Immunohistochemistry (2 μg/mL) & The optimal working dilution should be determined by the end user.

Alternative Names

matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IVcollagenase); MANDP2; CLG4B; matrix metalloproteinase 9 (gelatinase B, 92kD gelatinase, 92kD type IVcollagenase); matrix metalloproteinase 9 (gelatinase B, 92kDa gelatinase, 92kDa typ

Entrez Gene ID

UniProt ID

Antigen Description

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP"s are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades type IV and V collagens. Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow, and murine studies suggest a role in tumor-associated tissue remodeling.
Mouse monoclonal antibody raised against recombinant MMP9.

Pathway

Bladder cancer, organism-specific biosystem; Bladder cancer, conserved biosystem; CXCR4-mediated signaling events, organism-specific biosystem; Endochondral Ossification, organism-specific biosystem; FGF signaling pathway, organism-specific biosystem; IL-3 Signaling Pathway, organism-specific biosystem