Anti-MMP9 monoclonal antibody, clone 442DU28.5.5

Antibody Isotype

IgM

Clone

442DU28.5.5

Species Reactivity

Human

Conjugate

Application Notes

WB: 1:500-8000

Alternative Names

MMP9; CLG4B; Matrix metalloproteinase-9; 92 kDa gelatinase; 92 kDa type IV collagenase; Gelatinase B; 67 kDa matrix metalloproteinase-9; 82 kDa matrix metalloproteinase-9

Entrez Gene ID

UniProt ID

Antigen Description

Proteins of the matrix metalloproteinase (MMP) family areinvolved in the breakdown of extracellular matrix in normalphysiological processes, such as embryonic development,reproduction, and tissue remodeling, as well as in diseaseprocesses, such as arthritis and metastasis. Most MMP's aresecreted as inactive proproteins which are activated when cleavedby extracellular proteinases. The enzyme encoded by this genedegrades type IV and V collagens. Studies in rhesus monkeys suggestthat the enzyme is involved in IL-8-induced mobilization ofhematopoietic progenitor cells from bone marrow, and murine studiessuggest a role in tumor-associated tissue remodeling. [provided byRefSeq].

Pathway

AGE/RAGE pathway; Activation of Matrix Metalloproteinases; Angiogenesis; Assembly of collagen fibrils and other multimeric structures; Bladder cancer; CXCR4-mediated signaling events; Collagen degradation; Collagen formation;