Anti-Haptoglobin monoclonal antibody, clone 3G5

Antibody Isotype

IgG1

Clone

3G5

Species Reactivity

Human

Immunogen

Native purified human HP.

Conjugate

Application Notes

WB (1:2000); The optimal working dilution should be determined by the end user.

Alternative Names

haptoglobin; binding peptide; BP; haptoglobin alpha(1S)-beta; HP2ALPHA2; haptoglobin alpha(2FS)-beta; HPA1S; haptoglobin, alpha polypeptide; MGC111141; haptoglobin, beta polypeptide

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes a preproprotein, which is processed to yield both alpha and beta chains, which subsequently combine as a tetramer to produce haptoglobin. Haptoglobin functions to bind free plasma hemoglobin, which allows degradative enzymes to gain access to the hemoglobin, while at the same time preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin. Mutations in this gene and/or its regulatory regions cause ahaptoglobinemia or hypohaptoglobinemia. This gene has also been linked to diabetic nephropathy, the incidence of coronary artery disease in type 1 diabetes, Crohn"s disease, inflammatory disease behavior, primary sclerosing cholangitis, susceptibility to idiopathic Parkinson"s disease, and a reduced incidence of Plasmodium falciparum malaria. A similar duplicated gene is located next to this gene on chromosome 16. Multiple transcript variants encoding different isoforms have been found for this gene.
Mouse monoclonal antibody raised against native HP.

Pathway

amb2 Integrin signaling, organism-specific biosystem