Specifications
Immunogen
Human Haptoglobin
Target
Alternative Names
HP; haptoglobin; BP; HPA1S; HP2ALPHA2; MGC111141; HP2-ALPHA-2; Haptoglobin; Haptoglobin alpha chain; Haptoglobin beta chain; binding peptide; haptoglobin alpha(1S)-beta; haptoglobin alpha(2FS)-beta; haptoglobin, alpha polypeptide; haptoglobin, beta polype
Product Background
Antigen Description
Haptoglobin is ordered whenever a patient exhibits symptoms of anemia, such as pallor, fatigue, or shortness of breath, along with physical signs of hemolysis, such as jaundice or dark-colored urine. The test is also commonly ordered as a hemolytic anemia battery, which also includes a reticulocyte count and a peripheral blood smear. It can also be ordered along with a Direct Antiglobulin Test when a patient is suspected of having a transfusion reaction or symptoms of autoimmune hemolytic anemia. Also, it may be ordered in conjunction with a bilirubin.
Pathway
amb2 Integrin signaling
Citations
Publication ()
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Haptoglobin as a supplement in in vitro embryo culture: a tool for improving bovine embryo development and quality
Cañón-Beltrán K, Cajas YN, Martínez-López C, Moros-Nicolás C, Sòria-Monzó P, Balastegui-Alarcón M, Avilés M, Rizos D, García-Vázquez FA, Izquierdo-Rico MJ
Applications: IHC
Reactive species: Human
"Abstract: Recent studies have indicated the potential involvement of haptoglobin in a variety of events during mammalian reproduction, with previous research highlighting its efficacy in promoting porcine embryo development. The present study aims to provide a comprehensive investigation of haptoglobin expression and secretion in the bovine uterus, with a view to assessing its impact on bovine in vitro embryo production. A systematic study was conducted on cows in different oestrous stages, early follicular, late follicular, early luteal and late luteal stages. Relative haptoglobin mRNA abundance was quantified by RT-qPCR, and the expression of the protein was analysed by immunohistochemistry. The results were complemented by proteomic analyses of the uterine fluid. In vitro bovine fertilisation and embryo culture were carried out in the presence of haptoglobin."
Article snippet: After endogenous peroxidase blocking, sections were incubated for 20 min at 37 °C with normal horse serum (30022, Vector Labs., Burlingame, CA) to block endogenous background and then 4 °C overnight with the primary antibody (rabbit anti-human haptoglobin polyclonal antibody, Creative Diagnostics, NY 11967, USA) (dilution 1:1000). 
Figure 1. Immunohistochemical localization of haptoglobin in the bovine endometrium during different phases of the oestrous cycle.
COA
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