Specifications
Immunogen
CDK9 (AAH01968, 271 a.a. ~ 373 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Target
Alternative Names
cyclin-dependent kinase 9; cyclin-dependent kinase 9 (CDC2-related kinase); CDC2L4; CTK1; C-2k; CDC2-related kinase; PITALRE; serine/threonine protein kinase PITALRE; TAK; Cell division cycle 2-like protein kinase 4; EC 2.7.11.22; Cell division protein ki
Product Background
Antigen Description
The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and known as important cell cycle regulators. This kinase was found to be a component of the multiprotein complex TAK/P-TEFb, which is an elongation factor for RNA polymerase II-directed transcription and functions by phosphorylating the C-terminal domain of the largest subunit of RNA polymerase II. This protein forms a complex with and is regulated by its regulatory subunit cyclin T or cyclin K. HIV-1 Tat protein was found to interact with this protein and cyclin T, which suggested a possible involvement of this protein in AIDS.
Mouse monoclonal antibody raised against a partial recombinant CDK9.
Pathway
Androgen Receptor Signaling Pathway, organism-specific biosystem; Formation and Maturation of mRNA Transcript, organism-specific biosystem; Formation of HIV-1 elongation complex containing HIV-1 Tat, organism-specific biosystem; Formation of HIV-1 elongation complex in the absence of HIV-1 Tat, organism-specific biosystem; Formation of RNA Pol II elongation complex, organism-specific biosystem; Gene Expression, organism-specific biosystem
Citations
Publication ()
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COA
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