Member of the cyclin-dependent kinase pair (CDK9/cyclin-T) complex, also called positive transcription elongation factor b (P-TEFb), which facilitates the transition from abortive to production elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II), SUPT5H and RDBP. The CDK9/cyclin-K complex has also a kinase activity toward CTD of RNAP II and can substitute for P-TEFb in vitro.
Pathway
Androgen Receptor Signaling Pathway; Disease; Formation of HIV-1 elongation complex containing HIV-1 Tat; Formation of HIV-1 elongation complex in the absence of HIV-1 Tat; Formation of RNA Pol II elongation complex; Gene Expression; HIV Infection
Citations
Publication ()
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