MARCH8 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH8 induces the internalization of several membrane glycoproteins (Goto et al., 2003 [PubMed 12582153]; Bartee et al., 2004 [PubMed 14722266]).[supplied by OMIM, Apr 2010]
Function
MHC class II protein binding; ligase activity; ubiquitin-protein transferase activity; zinc ion binding
Synonyms
MARCH8; membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase; MIR; c-MIR; RNF178; MARCH-VIII; E3 ubiquitin-protein ligase MARCH8; RING finger protein 178; membrane-associated RING-CH protein VIII; membrane-associated RING finger protein 8; c-mir, cellular modulator of immune recognition; cellular modulator of immune recognition (c-MIR)
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