Human IMPDH1 peptide

Specificity

IMP type I is the main species in normal leukocytes and type II predominates over type I in the tumor.

Nature

Synthetic

Tag/Conjugate

Unconjugated

Format

Liquid

Preservative

None

Storage

Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. Information available upon request.

Gene ID

3614

UniProt ID

B3KRZ3

Antigen Description

The protein encoded by this gene acts as a homotetramer to regulate cell growth. The encoded protein is an enzyme that catalyzes the synthesis of xanthine monophosphate (XMP) from inosine-5-monophosphate (IMP). This is the rate-limiting step in the de novo synthesis of guanine nucleotides. Defects in this gene are a cause of retinitis pigmentosa type 10 (RP10). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]

Function

DNA binding; IMP dehydrogenase activity; RNA binding; adenyl nucleotide binding; metal ion binding; nucleic acid binding;

Synonyms

IMPDH1; IMP (inosine 5-monophosphate) dehydrogenase 1; IMPD; RP10; IMPD1; LCA11; sWSS2608; inosine-5-monophosphate dehydrogenase 1; IMPD 1; IMPDH 1; IMPDH-I; IMP dehydrogenase 1; IMP (inosine monophosphate) dehydrogenase 1;