Rabbit Anti-Human IL12RB1 (internal) Polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

Fusion protein corresponding to a region derived from internal residues of human interleukin 12 receptor, beta 1

Conjugate

Application Notes

IHC: 1:25-1:100

General Notes

This product (Catalog No. CABT-BL1915) is a rabbit-derived IgG polyclonal antibody raised against human IL12RB1. It has been affinity purified by protein A. The protein encoded by this gene is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukine 12 (IL12) with a low affinity, and is thought to be a part of IL12 receptor complex. This protein forms a disulfide-linked oligomer, which is required for its IL12 binding activity. The coexpression of this and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. Mutations in this gene impair the development of interleukin-17-producing T lymphocytes and result in increased susceptibility to mycobacterial and Salmonella infections. Alternative splicing results in multiple transcript variants.
CABT-BL1915 is suitable for use in IHC (1:25–1:100) application.
CABT-BL1915 is supplied as a liquid formulation in pH7.4 PBS, 0.05% sodium azide, 40% Glycerol. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.

Alternative Names

CD212; IL12RB; IL-12R-BETA1

Entrez Gene ID

UniProt ID