Anti-CD3E monoclonal antibody, clone 611B3

Antibody Isotype

IgG

Clone

611B3

Species Reactivity

Mouse

Immunogen

Native Cd3e from mouse T cell receptor complexes.

Conjugate

Alternative Names

FLJ18683; TCRE; T3E; T-cell antigen receptor complex, epsilon subunit of T3; T-cell surface antigen T3/Leu-4 epsilon chain; T-cell surface glycoprotein CD3 epsilon chain; CD3-epsilon; OTTHUMP00000234559; OTTHUMP00000234560; CD3e antigen, epsilon polypepti

Entrez Gene ID

UniProt ID

Antigen Description

The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women.
Hamster monoclonal antibody raised against native Cd3e.

Pathway

Adaptive Immunity Signaling, organism-specific biosystem; CXCR4-mediated signaling events, organism-specific biosystem; Chagas disease (American trypanosomiasis), organism-specific biosystem; Chagas disease (American trypanosomiasis), conserved biosystem; Costimulation by the CD28 family, organism-specific biosystem; Downstream TCR signaling, organism-specific biosystem