Anti-CD3E monoclonal antibody, clone NN0278-4G54

Antibody Isotype

IgG1

Clone

NN0278-4G54

Species Reactivity

Human

Immunogen

Human recombinant CD3 epsilon

Conjugate

Application Notes

IHC-Fr: 1/50 - 1/100; Flow Cyt: 1/50 - 1/100;

Alternative Names

CD3E; CD3e molecule, epsilon (CD3-TCR complex); CD3e antigen, epsilon polypeptide (TiT3 complex); T-cell surface glycoprotein CD3 epsilon chain; CD3E; CD3E antigen epsilon polypeptide; CD3e molecule epsilon; CD3E_HUMAN; T cell surface antigen T3/Leu 4 eps

Entrez Gene ID

UniProt ID

Antigen Description

Cytochrome c oxidase (COX), the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may be involved in the regulation and assembly of the complex. This nuclear gene encodes subunit VIb. Mutations in this gene are associated with severe infantile encephalomyopathy. Three pseudogenes COX6BP-1, COX6BP-2 and COX6BP-3 have been found on chromosomes 7, 17 and 22q13.1-13.2, respectively.

Pathway

Adaptive Immune System, organism-specific biosystem; CXCR4-mediated signaling events, organism-specific biosystem; Chagas disease (American trypanosomiasis), organism-specific biosystem; Chagas disease (American trypanosomiasis), conserved biosystem; Costimulation by the CD28 family, organism-specific biosystem; Downstream TCR signaling, organism-specific biosystem; Downstream signaling in naive CD8+ T cells, organism-specific biosystem; Generation of second messenger molecules, organism-specifi