Anti-GRAP2 monoclonal antibody (DMABT-H13867)

Mouse anti-Human GRAP2 monoclonal antibody for WB, IHC, IP, sELISA, ELISA Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG2a
Clone
2H23
Species Reactivity
Human
Immunogen
GRAP2 (AAH25692, 226 a.a. ~ 315 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Unconjugated

Target


Alternative Names
GRAP2; GRB2-related adaptor protein 2; GRB2-related adapter protein 2; GADS; GRBLG; GrbX
Entrez Gene ID
UniProt ID

Product Background


Gene summary
GRAP2 (GRB2-Related Adaptor Protein 2) is a Protein Coding gene. Diseases associated with GRAP2 include potters syndrome and ovarian carcinosarcoma. Among its related pathways are Signaling by GPCR and Immune System. GO annotations related to this gene include SH3/SH2 adaptor activity. An important paralog of this gene is GRAPL. This gene encodes a member of the GRB2/Sem5/Drk family. This member is an adaptor-like protein involved in leukocyte-specific protein-tyrosine kinase signaling. Like its related family member, GRB2-related adaptor protein (GRAP), this protein contains an SH2 domain flanked by two SH3 domains. This protein interacts with other proteins, such as GRB2-associated binding protein 1 (GAB1) and the SLP-76 leukocyte protein (LCP2), through its SH3 domains. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Antigen Description
Interacts with SLP-76 to regulate NF-AT activation. Binds to tyrosine-phosphorylated shc. GRB2-related adapter protein 2 also known as GRB2-related adaptor downstream of Shc (GADS) is a 37 kDa protein that in humans is encoded by the GRAP2 gene. This gene encodes a member of the GRB2/Sem5/Drk family. This member is an adaptor-like protein involved in leukocyte-specific protein-tyrosine kinase signaling. Like its related family member, GRB2-related adaptor protein (GRAP), this protein contains an SH2 domain flanked by two SH3 domains. This protein interacts with other proteins, such as GRB2-associated binding protein 1 (GAB1) and the SLP-76 leukocyte protein (LCP2), through its SH3 domains. Transcript variants utilizing alternative polyA sites exist. The function about GRAP2 antigen include SH3/SH2 adaptor activity; protein binding.
Pathway
Adaptive Immune System, organism-specific biosystem; CD28 co-stimulation, organism-specific biosystem; Costimulation by the CD28 family, organism-specific biosystem; Generation of second messenger molecules, organism-specific biosystem; Immune System, organism-specific biosystem; JNK signaling in the CD4+ TCR pathway, organism-specific biosystem; Signal Transduction, organism-specific biosystem.

Citations


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References


Bade, B; Boettcher, HE; et al. Differential expression of the granzymes A, K and M and perforin in human peripheral blood lymphocytes. INTERNATIONAL IMMUNOLOGY 17:1419-1428(2005).

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We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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