Human GFI1 peptide

Nature

Synthetic

Tag/Conjugate

Unconjugated

Alternative Names

The Gly/Ala-rich region may indicate that Gfi-1 is a repressor of its target genes.

Format

Liquid

Preservative

None

Storage

Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. Information available upon request.

Gene ID

2672

UniProt ID

B3KVN4

Antigen Description

This gene encodes a nuclear zinc finger protein that functions as a transcriptional repressor. This protein plays a role in diverse developmental contexts, including hematopoiesis and oncogenesis. It functions as part of a complex along with other cofactors to control histone modifications that lead to silencing of the target gene promoters. Mutations in this gene cause autosomal dominant severe congenital neutropenia, and also dominant nonimmune chronic idiopathic neutropenia of adults, which are heterogeneous hematopoietic disorders that cause predispositions to leukemias and infections. Multiple alternatively spliced variants, encoding the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008]

Function

RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription; protein binding; transcription regulatory region DNA binding; zinc ion binding;

Synonyms

GFI1; growth factor independent 1 transcription repressor; SCN2; GFI-1; GFI1A; ZNF163; zinc finger protein Gfi-1; zinc finger protein 163; growth factor independence-1; growth factor independent protein 1;