Anti-GFI1 monoclonal antibody, clone 6E8

Antibody Isotype

IgG1

Clone

6E8

Species Reactivity

Human

Immunogen

Recombinant protein corresponding to human GFI1.

Conjugate

Application Notes

ELISA (1:10000); WB (1:500-1:2000) & The optimal working dilution should be determined by the end user.

Alternative Names

GFI1; growth factor independent 1 transcription repressor; growth factor independent 1 , ZNF163; zinc finger protein Gfi-1; zinc finger protein 163; growth factor independence-1; growth factor independent protein 1; SCN2; GFI-1; ZNF163; FLJ94509;

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes a nuclear zinc finger protein that functions as a transcriptional repressor. This protein plays a role in diverse developmental contexts, including hematopoiesis and oncogenesis. It functions as part of a complex along with other cofactors to control histone modifications that lead to silencing of the target gene promoters. Mutations in this gene cause autosomal dominant severe congenital neutropenia, and also dominant nonimmune chronic idiopathic neutropenia of adults, which are heterogeneous hematopoietic disorders that cause predispositions to leukemias and infections. Multiple alternatively spliced variants, encoding the same protein, have been identified for this gene.

Pathway

Validated targets of C-MYC transcriptional repression, organism-specific biosystem;