Product Overview
Blocking/Immunizing peptide for anti-GATA1 antibody
Tag/Conjugate
Unconjugated
Application Notes
For in vitro research use only. Not intended for any diagnostic or therapeutic purpose. Not for human or animal consumption.
Format
Lyophilized powder
Storage
Shipped at ambient temperature, store at -20°C.
Antigen Description
This gene encodes a protein which belongs to the GATA family of transcription factors. The protein plays an important role in erythroid development by regulating the switch of fetal hemoglobin to adult hemoglobin. Mutations in this gene have been associated with X-linked dyserythropoietic anemia and thrombocytopenia.
Function
C2H2 zinc finger domain binding; DNA binding; DNA binding, bending; RNA polymerase II core promoter proximal region sequence-specific DNA binding; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity
Synonyms
GATA1; GATA binding protein 1 (globin transcription factor 1); GATA binding protein 1 (globin transcription factor 1) , GF1; erythroid transcription factor; ERYF1; GATA 1; NFE1; GATA-binding factor 1; NF-E1 DNA-binding protein; transcription factor GATA1; globin transcription factor 1; erythroid transcription factor 1; GF1; GF-1; XLTT; GATA-1;
Citations
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Lunardi, C; Tinazzi, E; et al. Human parvovirus B19 infection and autoimmunity. AUTOIMMUNITY REVIEWS 8:116-120(2008).
Freson, K; Peeters, K; et al. PACAP and its receptor VPAC1 regulate megakaryocyte maturation: therapeutic implications. BLOOD 111:1885-1893(2008).