Fenpropathrin [KLH]

Aquatic organisms are usually exposed to various co-existing pollutants. However, toxic effects of pesticide mixtures on aquatic organisms and its potential underlying mechanism still remain unclear. The joint effects of fenpropathrin (FEN) and paclobutrazol (PAC) on zebrafish (Danio rerio) using diverse toxicological endpoints were investigated in the current work. Our data exhibited that the 96-h LC50 values of FEN to zebrafish at multiple life phases ranged from 0.0029 (0.0013-0.0042) to 0.16 (0.082 -0.23) mg a.i. L-1, which were lower by comparison to PAC ranging from 13.16 (8.564-21.03) to 23.43 (17.94-29.91) mg a.i. L-1. Combination of FEN and PAC displayed synergistic effect on embryonic zebrafish. Activities of T-SOD, Cu/Zn-SOD and CYP450 were remarkably changed in the majority of single and mixture treatments by comparison to the untreated group. The mRNA levels of 17 genes related to oxidative stress, cellular apoptosis, immune system and endocrine system were assessed, and the data suggested that embryonic zebrafish were affected by both single pesticides and their mixtures. Five genes (P53, tsh, ER alpha, crh and cxcl-clc) showed greater alterations when exposed to pesticide mixtures by comparison to their individual chemicals. Therefore, it is urgently necessary to conduct more studies on mixture toxicities of different pesticides to explore the chemical mixtures with synergistic interactions. (C) 2020 Elsevier Ltd. All rights reserved.

This study focused on contamination levels and spatial distributions of four common pyrethroids found in agricultural soils of the Yangtze River Delta (YRD), China. Pyrethroids were detected in 241 soil samples (88.8% detection rate) with total concentrations ranging from cypermethrin (1.10 ng/g) > deltamethrin (0.89 ng/g) > cyhalothrin (0.20 ng/g). The highest concentration of fenpropathrin was recorded as 37.6 ng/g. The highest detection rate of 63.9% was found for cyhalothrin. A distinct pattern of spatial distribution was observed where high concentrations of pyrethroids were detected in sites around Taihu Lake. Potential sources of pyrethroids in agricultural soils from the YRD region include pyrethroids used for pest control and wastewater irrigation in the region. Redundancy and correlation analyses show that the soil TOC values have played a significant role in the behavior of pyrethroids in agricultural soils of the YRD region. Potential ecological risks of pyrethroids in agricultural soils of the YRD region are low. Cypermethrin and cyhalothrin showed potential toxic effects on the ecological conditions of agricultural soils in 4.6% and 2.9% of the sampling sites, respectively. Further studies should pay more attention to the potential human health risks posed by pyrethroids in agricultural soils for the protection of soil quality and food safety. (C) 2020 Elsevier B.V. All rights reserved.