Human MECOM blocking peptide

Product Overview

Blocking/Immunizing peptide for anti-EVI1/ AML1 antibody

Target

EVI1 / AML1

Nature

Synthetic

Tag/Conjugate

Unconjugated

Application Notes

For in vitro research use only. Not intended for any diagnostic or therapeutic purpose. Not for human or animal consumption.

Format

Lyophilized powder

Preservative

None

Storage

Shipped at ambient temperature, store at -20°C.

Gene ID

2122

UniProt ID

Q03112

Antigen Description

The protein encoded by this gene is a transcriptional regulator and oncoprotein that may be involved in hematopoiesis, apoptosis, development, and cell differentiation and proliferation. The encoded protein can interact with CTBP1, SMAD3, CREBBP, KAT2B, MAPK8, and MAPK9. This gene can undergo translocation with the AML1 gene, resulting in overexpression of this gene and the onset of leukemia. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]

Function

DNA binding; metal ion binding; protein binding; protein homodimerization activity; NOT protein homodimerization activity; sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding transcription factor activity;

Synonyms

MECOM; MDS1 and EVI1 complex locus; EVI1; MDS1; PRDM3; MDS1-EVI1; AML1-EVI-1; MDS1 and EVI1 complex locus protein EVI1; oncogene EVI1; zinc finger protein Evi1; AML1-EVI-1 fusion protein; MDS1 and EVI1 complex locus protein MDS1; myelodysplasia syndrome-associated protein 1; ecotropic virus integration site 1 protein homolog;