Product Overview
Blocking/Immunizing peptide for anti-Choline acetyltransferase antibody
Target
Choline acetyltransferase
Tag/Conjugate
Unconjugated
Application Notes
For in vitro research use only. Not intended for any diagnostic or therapeutic purpose. Not for human or animal consumption.
Format
Lyophilized powder
Storage
Shipped at ambient temperature, store at -20°C.
Antigen Description
This gene encodes an enzyme which catalyzes the biosynthesis of the neurotransmitter acetylcholine. This gene product is a characteristic feature of cholinergic neurons, and changes in these neurons may explain some of the symptoms of Alzheimer's disease. Polymorphisms in this gene have been associated with Alzheimer's disease and mild cognitive impairment. Mutations in this gene are associated with congenital myasthenic syndrome associated with episodic apnea. Multiple transcript variants encoding different isoforms have been found for this gene, and some of these variants have been shown to encode more than one isoform. [provided by RefSeq, May 2010]
Function
choline O-acetyltransferase activity;
Synonyms
CHAT; choline O-acetyltransferase; CMS1A; CMS1A2; CHOACTASE; choline acetylase; acetyl CoA:choline O-acetyltransferase;
Citations
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Yu, JG; Kimura, T; et al. Segregation of VIPergic-nitric oxidergic and cholinergic-nitric oxidergic innervation in porcine middle cerebral arteries. BRAIN RESEARCH 801:78-87(1998).
Simon, DI; Chen, ZP; et al. Platelet glycoprotein Ib alpha is a counterreceptor for the leukocyte integrin Mac-1 (CD11b/CD18). JOURNAL OF EXPERIMENTAL MEDICINE 192:193-204(2000).