Specificity
Predominantly expressed in the thymus, in peripheral blood leukocytes, including T-cells, mostly CD4+ cells, and basophils, and in platelets; at lower levels, in the spleen and in monocytes. Detected also in macrophages, IL-2-activated natural killer cell
Tag/Conjugate
Unconjugated
SequenceSimilarities
Belongs to the G-protein coupled receptor 1 family.
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. Information available upon request.
Antigen Description
High affinity receptor for the C-C type chemokines CCL17/TARC and CCL22/MDC. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival.
Function
C-C chemokine receptor activity; G-protein coupled receptor activity; chemokine receptor activity; signal transducer activity;
Synonyms
CCR4; chemokine (C-C motif) receptor 4; LESTR; Sdf1r; CHEMR1; Cmkbr4; C-C CKR-4; C-C chemokine receptor type 4; fusin; chemokine (C-C) receptor 4; leukocyte-expressed seven-transmembrane-domain receptor;
Citations
Publication ()
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COA
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