Synthetic peptide designed within internal sequence amino acids 179-228: TERNHTYCKT KYSLNSTTWK VLSSLEINIL GLVIPLGIML FCYSMIIRTL, of Human CCR4 (NP_005499)
High affinity receptor for the C-C type chemokines CCL17/TARC and CCL22/MDC. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival.
Pathway
Chemokine receptors bind chemokines; Chemokine signaling pathway; Class A/1 (Rhodopsin-like receptors); Cytokine-cytokine receptor interaction; G alpha (i) signalling events;
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