Synthetic Human Bcl10 blocking peptide for BL, WB
BcL10 ( N - term ) peptide ( human )
PBS with 0.1% BSA 0.02% sodium azide pH7.2
Upon Receipt - Keep as concentrated solution. Aliquot and store at -20oC or below. Avoid freeze-thaw cycles.
This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy.
NF-kappaB binding; enzyme binding; contributes_to kinase activator activity; kinase binding; protease binding; protein C-terminus binding; protein binding; protein kinase B binding; protein kinase binding; protein self-association; transcription coactivat
BCL10; B-cell CLL/lymphoma 10; B-cell lymphoma/leukemia 10; c E10; CARD containing molecule enhancing NF kB; CARD containing apoptotic signaling protein; CARD containing proapoptotic protein; CARD like apoptotic protein; CARMEN; caspase recruiting domain containing protein; CIPER; CLAP; mE10; hCLAP; cCARMEN; cellular-E10; cellular homolog of vCARMEN; CARD-containing proapoptotic protein; CARD containing molecule enhancing NF-kB; CARD-containing apoptotic signaling protein; caspase-recruiting domain-containing protein; CARD-containing molecule enhancing NF-kappa-B; mammalian CARD-containing adapter molecule E10; CED-3/ICH-1 prodomain homologous E10-like regulator; c-E10;