Bacitracin [HRP]

Product Overview

Bacitracin, HRP conjugate

Target

Bacitracin

Nature

Synthetic

Tag/Conjugate

HRP

Format

Concentrate

Preservative

None

Storage

2-8°C short term, -20°C long term

Introduction

Bacitracin is a mixture of related cyclic polypeptides produced by organisms of the licheniformis group of Bacillus subtilis var Tracy, first isolated in 1945. These peptides disrupt both gram positive and gram negative bacteria by interfering with cell wall and peptidoglycan synthesis. Bacitracin is used as a topical preparation (since it is toxic and has poor oral bioavailability). In terms of adverse reactions only, in comparison with bacitracin, white petrolatum possesses an equally low infection rate and minimal risk for induction of allergy.

Antigen Description

Bacitracin is a mixture of related cyclic polypeptides produced by a member of the Bacillus subtilis group. Unlike most antibiotics its use is limited in oral administration and typical methods of application are by adsorption through the skin where the drug degrades the bacterial cell wall in Gram positive bacteria by blocking the dephosphorylation of the C55-isoprenyl pyrophosphate, an important molecule in the process of building the bacterial cell wall. Its main application is for fowl animals such as chickens in the form of an antibiotic drug and no MRLs have yet been established for this drug.

Keywords

Bacitracin