General Notes
This product (Catalog No. DPABH-26501) is a rabbit-derived polyclonal antibody raised against human VAMP1, targeting the amino acid region 2–96 of the protein. It has been affinity purified by Protein A. VAMP1, or vesicle-associated membrane protein 1 (also known as synaptobrevin-1), is a small integral membrane protein encoded by the VAMP1 gene located on the short arm of chromosome 12 (12p13.31) in humans. It serves as a core component of the SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) complex, which drives the calcium-triggered fusion of synaptic vesicles with the presynaptic plasma membrane, thereby facilitating neurotransmitter release essential for synaptic transmission in the nervous system. The protein consists of approximately 118 amino acids in its primary neuronal isoform (VAMP1A), featuring a proline- and glycine-rich cytoplasmic N-terminal domain, a conserved SNARE motif, a transmembrane domain anchoring it to vesicle membranes, and a short C-terminal intravesicular tail.
DPABH-26501 is suitable for use in ELISA (1:4,000–1:8,000), IHC (1:50–1:100), Western blot (WB) (1:1,000–1:4,000) applications.
DPABH-26501 is supplied as a liquid formulation in 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
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