Anti-VAMP1 monoclonal antibody, clone 5F351

Antibody Isotype

IgM

Clone

5F351

Species Reactivity

Mouse; Rat; Sheep; Rabbit; Guinea pig; Hamster; Cow; Human; Pig; Xenopus laevis; Monkey

Immunogen

Tissue/ cell preparation (Human). Mice were immunized with synaptic vesicle containing fractions which were immunoprecipitated from human brain homogenates using anti-human synaptophysin monoclonal antibodies.

Conjugate

Application Notes

WB: 1/1000;

Alternative Names

VAMP1; vesicle-associated membrane protein 1 (synaptobrevin 1); SYB1; vesicle-associated membrane protein 1; VAMP 1; synaptobrevin 1; synaptobrevin-1; VAMP-1; DKFZp686H12131;

Entrez Gene ID

UniProt ID

Antigen Description

Synaptobrevins are highly conserved between vertebrates and invertebrates. It is a major constituent of synaptic vesicles and peptidergic secretory granules in all neurons examined so far. In addition, it is present on secretory granules of neuroendocrine cells. Synaptobrevins, Syntaxins, and the 25 kDa synaptosomal associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane.

Pathway

BoNT Light Chain Types B, D, and F cleave VAMP/Synaptobrevin, organism-specific biosystem; Botulinum neurotoxicity, organism-specific biosystem; Disease, organism-specific biosystem; Neuronal System, organism-specific biosystem; Proteolytic cleavage of SNARE complex proteins, organism-specific biosystem; SNARE interactions in vesicular transport, organism-specific biosystem; SNARE interactions in vesicular transport, conserved biosystem;