TYMS (AAH13919, 111 a.a. ~ 210 a.a) partial recombinant protein with GST tag. The sequence is ANGSRDFLDSLGFSTREEGDLGPVYGFQWRHFGAEYRDMESDYSGQGVDQLQRVIDTIKT NPDDRRIIMCAWNPRDLPLMALPPCHALCQFYVVNSELSC
Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occuring antisense transcript rTSalpha (GeneID:55556) vary inversely when cell-growth progresses from late-log to plateau phase.
Pathway
Cell Cycle; E2F mediated regulation of DNA replication; Fluoropyrimidine Activity; G1/S-Specific Transcription
Citations
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