Anti-Human Thymidylate Synthase monoclonal antibody (DCABH-165)

Rabbit Anti-Human Thymidylate Synthase monoclonal antibody for IHC-P Datasheet

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Host Species
Antibody Isotype
Species Reactivity
Synthetic peptide near C-terminus of human TS.


Application Notes
Recommended dilution:
IHC-P: 1:100
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Data Examples

Immunohistochemical analysis of Thymidylate Synthase using anti-Thymidylate Synthase Monoclonal Antibody in Colon Adenocarcinoma Cancer Tissue. The recommened dilution for this antibody in immunohistochemistry applications is 1:100.


Alternative Names
TYMS; thymidylate synthetase; TS; TMS; HST422; thymidylate synthase
Entrez Gene ID
UniProt ID

Product Background

Gene summary
TYMS (Thymidylate Synthetase) is a Protein Coding gene. Diseases associated with TYMS include timothy syndrome and brugada syndrome 3. Among its related pathways are Metabolism and Cell Cycle, Mitotic. GO annotations related to this gene include protein homodimerization activity and mRNA binding. Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occuring antisense transcript rTSalpha (GeneID:55556) vary inversely when cell-growth progresses from late-log to plateau phase.
Antigen Description
Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Thymidylate synthetase (EC 2. 1. 45) is an enzyme that catalyzes the conversion of deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP). Thymidine is one of the nucleotides in DNA. With inhibition of TS, an imbalance of deoxynucleotides and increased levels of dUTP arise. Both cause DNA damage. The following reaction is catalyzed by thymidylate synthetase:.


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Shebzukhov, YV; Koroleva, EP; et al. Humoral immune response to thymidylate synthase in colon cancer patients after 5-FU chemotherapy. IMMUNOLOGY LETTERS 100:88-93(2005).
Bissoon-Haqqani, S; Moyana, T; et al. Nuclear expression of thymidylate synthase in colorectal cancer cell lines and clinical samples. JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY 54:19-29(2006).

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