Anti-Human Thymidylate Synthase monoclonal antibody (DCABH-165)
Rabbit Anti-Human Thymidylate Synthase monoclonal antibody for IHC-P
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Synthetic peptide near C-terminus of human TS.
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.
Immunohistochemical analysis of Thymidylate Synthase using anti-Thymidylate Synthase Monoclonal Antibody in Colon Adenocarcinoma Cancer Tissue. The recommened dilution for this antibody in immunohistochemistry applications is 1:100.
TYMS; thymidylate synthetase; TS; TMS; HST422; thymidylate synthase
TYMS (Thymidylate Synthetase) is a Protein Coding gene. Diseases associated with TYMS include timothy syndrome and brugada syndrome 3. Among its related pathways are Metabolism and Cell Cycle, Mitotic. GO annotations related to this gene include protein homodimerization activity and mRNA binding. Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occuring antisense transcript rTSalpha (GeneID:55556) vary inversely when cell-growth progresses from late-log to plateau phase.
Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Thymidylate synthetase (EC 2. 1. 45) is an enzyme that catalyzes the conversion of deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP). Thymidine is one of the nucleotides in DNA. With inhibition of TS, an imbalance of deoxynucleotides and increased levels of dUTP arise. Both cause DNA damage. The following reaction is catalyzed by thymidylate synthetase:.
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Kobunai, T; Watanabe, T; et al. Antitumour Activity of S-1 in Combination with Cetuximab on Human Gastric Cancer Cell Lines In Vivo. ANTICANCER RESEARCH 31:3691-3696(2011).
Laurent-Puig, P; Lievre, A; et al. The biological point of view on pharmacogenetics of anticancer agents in colorectal cancer. BULLETIN DU CANCER 95:935-942(2008).
Custom Antibody Labeling
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody.