Synthetic peptide: TKRSGASILQAGC, corresponding to C terminal amino acids 537-549 of Human TXNRD1 (NP_003321).
Conjugate
Unconjugated
Applications
Application Notes
Peptide ELISA: Antibody detection limit dilution >1/32000. WB: Use at a concentration of 0.1 - 1 μg/ml. Detects a band of approximately 60 kDa (predicted molecular weight: 55 kDa).
Target
Alternative Names
TXNRD1; thioredoxin reductase 1; thioredoxin reductase 1, cytoplasmic; GRIM 12; Trxr1; TXNR; oxidoreductase; thioredoxin reductase TR1; thioredoxin reductase GRIM-12; KM-102-derived reductase-like factor; gene associated with retinoic and IFN-induced mort
Isoform 1 may possess glutaredoxin activity as well as thioredoxin reductase activity and induces actin and tubulin polymerization, leading to formation of cell membrane protrusions. Isoform 4 enhances the transcriptional activity of estrogen receptors alpha and beta while isoform 5 enhances the transcriptional activity of the beta receptor only. Isoform 5 also mediates cell death induced by a combination of interferon-beta and retinoic acid.
Pathway
Fatty acid, triacylglycerol, and ketone body metabolism; Metabolism; Metabolism of lipids and lipoproteins; Metabolism of nucleotides; Oxidative Stress; PPARA Activates Gene Expression; Pyrimidine metabolism
Citations
Publication ()
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