Isoform 1 may possess glutaredoxin activity as well as thioredoxin reductase activity and induces actin and tubulin polymerization, leading to formation of cell membrane protrusions. Isoform 4 enhances the transcriptional activity of estrogen receptors alpha and beta while isoform 5 enhances the transcriptional activity of the beta receptor only. Isoform 5 also mediates cell death induced by a combination of interferon-beta and retinoic acid.
Pathway
Fatty acid, triacylglycerol, and ketone body metabolism; Metabolism; Metabolism of lipids and lipoproteins; Metabolism of nucleotides; Oxidative Stress; PPARA Activates Gene Expression; Pyrimidine metabolism
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