Specifications
Species Reactivity
Rat; Human
Immunogen
Synthetic peptide, corresponding to residues in Human TXNRD1 (UniProt: Q16881).
Applications
Application Notes
WB: 1/1000 - 1/5000; IHC-P: 1/100 - 1/250; ICC/IF: 1/250 - 1/500; Flow Cyt: 1/100 - 1/500;
Target
Alternative Names
TXNRD1; thioredoxin reductase 1; thioredoxin reductase 1, cytoplasmic; GRIM 12; Trxr1; TXNR; oxidoreductase; thioredoxin reductase TR1; thioredoxin reductase GRIM-12; KM-102-derived reductase-like factor; gene associated with retinoic and IFN-induced mort
Product Background
Antigen Description
Isoform 1 may possess glutaredoxin activity as well as thioredoxin reductase activity and induces actin and tubulin polymerization, leading to formation of cell membrane protrusions. Isoform 4 enhances the transcriptional activity of estrogen receptors alpha and beta while isoform 5 enhances the transcriptional activity of the beta receptor only. Isoform 5 also mediates cell death induced by a combination of interferon-beta and retinoic acid.
Pathway
Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystem; Metabolism, organism-specific biosystem; Metabolism of lipids and lipoproteins, organism-specific biosystem; Metabolism of nucleotides, organism-specific biosystem; Oxidative Stress, organism-specific biosystem; PPARA Activates Gene Expression, organism-specific biosystem; Pyrimidine metabolism, organism-specific biosystem;
Citations
Publication ()
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COA
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