Anti-NTRK1 monoclonal antibody, clone 2.B.48

Antibody Isotype

IgG

Clone

2.B.48

Species Reactivity

Virus

Immunogen

Purified trKB receptors from insect cells (sf9) transfected with Baculovirus.

Conjugate

Application Notes

WB: Use at an assay dependent dilution. Predicted molecular weight: 92 kDa; IP: Use at an assay dependent dilution.

Alternative Names

NTRK1; neurotrophic tyrosine kinase, receptor, type 1; high affinity nerve growth factor receptor; MTC; TRK; TRKA; gp140trk; Oncogene TRK; tyrosine kinase receptor A; tropomyosin-related kinase A; TRK1-transforming tyrosine kinase protein; TRK1; Trk-A; p1

Entrez Gene ID

UniProt ID

Antigen Description

Neurotrophins activate tyrosine kinase receptors of the TRK family (TRKA, TRKB and TRKC) and they all share a common low affinity receptor (p75NTR or p75). Although p75NTR does not appear to directly transduce NGF signals, this receptor appears to increase the responsiveness of the TRK receptors and plays a role in the retrograde transport of neurotrophin signals from axon terminals to the cell body. The expression of trk gene neurotrophin receptors in mouse is tabulated by Barbacid (1994). NGF binds with high affinity and activates the TRKA tyrosine kinase receptor, which is apparently responsible for signal transduction. BDNF activates the TRKB tyrosine kinase receptor, which it shares with NT-4. NT-3 activates the TrkC tyrosine kinase receptor, but can also activate TRKA and TRKB receptors in certain cell systems. NT-4 primarily activates the TRKB tyrosine kinase receptor, which it shares with BDNF.

Pathway

ARMS-mediated activation, organism-specific biosystem; Activation of TRKA receptors, organism-specific biosystem; Apoptosis, organism-specific biosystem; Apoptosis, conserved biosystem; Endocytosis, organism-specific biosystem; Endocytosis, conserved biosystem; Frs2-mediated activation, organism-specific biosystem;