Anti-NTRK1 monoclonal antibody, clone 7C3

Clone

7C3

Species Reactivity

Human

Immunogen

Recombinant protein corresponding to human NTRK1.

Conjugate

Application Notes

WB (1:500-1:2000); Immunofluorescence (1:200-1:1000); ELISA (1:10000) & The optimal working dilution should be determined by the end user.

Alternative Names

NTRK1; neurotrophic tyrosine kinase, receptor, type 1; high affinity nerve growth factor receptor; MTC; TRK; TRKA; gp140trk; Oncogene TRK; tyrosine kinase receptor A; tropomyosin-related kinase A; TRK1-transforming tyrosine kinase protein; TRK1; Trk-A; p1

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date.

Pathway

ARMS-mediated activation, organism-specific biosystem; Activation of TRKA receptors, organism-specific biosystem; Apoptosis, organism-specific biosystem; Apoptosis, conserved biosystem; Endocytosis, organism-specific biosystem; Endocytosis, conserved biosystem; Frs2-mediated activation, organism-specific biosystem;